The free show named Liverpool Dreams will take place in the city and Wirral over four days from 4-7 October.
The event by French company Royal de Luxe will be the final part in a trilogy, following on from events in 2012 and 2014 and will be a key part in the city’s 2018 celebrations marking 10 years since Liverpool was European Capital of Culture.
Liverpool Mayor Joe Anderson has proclaimed it as “one of the great events that the city will talk about”.
The giants taking part in the performance will be announced soon, with the route to be revealed in September.
Jean Luc Courcoult, founder and artistic director of Royal de Luxe, said: “The welcome we receive from the people of the city warms our hearts and we are excited about not only bringing a brand new story to Liverpool, but also to exploring beautiful Wirral for the first time.”
Although it will be the Giants’ last outing in Liverpool, Mr Anderson said it is “not the end of spectacular theatre in Liverpool, we will continue to push the boundaries in that regard.”